Calcium D-Glucarate for Estrogen Dominance & Detoxification

by Christina

Calcium D-glucarate is a compound that has gained attention for its potential health benefits, particularly for women.

Maintaining hormonal balance is essential for overall well-being. Hormones are crucial in our body’s functions, including metabolism, mood regulation, and reproductive health. However, factors like stress, diet, menopause and environmental toxins can disrupt the delicate hormonal equilibrium, leading to various health issues.

Whether you are seeking to support hormone balance, reduce the risk of hormone-dependent cancers, or enhance liver detoxification, this article will provide you with the information you need to make informed decisions about incorporating calcium D-glucarate into your wellness routine.

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What is calcium D-glucarate?

Calcium D-glucarate is a calcium salt of D-glucaric acid, a non-toxic compound present in many fruits and vegetables. While it occurs naturally in foods like grapefruits, apples, oranges, and cruciferous vegetables, the amounts are relatively small. Calcium D-glucarate is available as a dietary supplement, offering a concentrated form of this beneficial compound.

To understand the role of calcium D-glucarate in hormone regulation, it’s essential to understand the liver’s detoxification process. The liver is responsible for filtering out toxins and waste products from the body.

One of the liver’s key detoxification pathways, known as Phase II detoxification, involves a process called glucuronidation. During glucuronidation, the liver processes end-metabolite hormones, such as estrogen, to facilitate their safe elimination from the body. This process is vital for maintaining hormonal balance.

Beta-glucuronidase is an enzyme the colonic microbiota produces that plays a significant role in liver detoxification. However, when the gut microbiome is compromised, beta-glucuronidase can be produced excessively, leading to imbalances in hormone metabolism. Dysbiosis, a condition characterized by an imbalance in gut bacteria, can result from factors such as antibiotic use or a poor diet. Excessive beta-glucuronidase activity can interfere with the liver’s detoxification process, hindering the proper elimination of hormonal metabolites.

The Benefits of Calcium D-Glucarate

Promoting Estrogen Clearance

Estrogen dominance, a condition characterized by an imbalance between estrogen and progesterone levels, can have profound effects on health. Elevated levels of estrogen are associated with various conditions, including obesity, metabolic syndrome, polycystic ovary syndrome (PCOS), cardiovascular disease, and hormone-dependent cancers like breast cancer.

Calcium D-glucarate has been shown to support estrogen clearance by inhibiting beta-glucuronidase. By preventing excessive beta-glucuronidase activity, calcium D-glucarate helps ensure that estrogen metabolites are properly conjugated and excreted from the body.

Potential Cancer Prevention

Studies suggest that calcium D-glucarate may have protective properties against certain types of cancer, particularly breast cancer. Research conducted on mice models indicates that d-glucarates can suppress cell proliferation, reduce inflammation, and induce cell apoptosis. These effects help maintain healthy cell turnover and prevent the development of malignancies. Other compounds found in cruciferous vegetables, such as diindolylmethane (DIM) and isothiocyanates like sulforaphane, also show the potential to inhibit breast cancer. Incorporating sulphur-rich foods into your diet, alongside calcium D-glucarate supplementation, may provide additional support in reducing cancer risk.

Liver Health and Detoxification

As a supplement, calcium D-glucarate supports liver health and detoxification. By inhibiting beta-glucuronidase, it helps maintain the integrity of the liver’s detoxification pathway. This promotes the efficient elimination of toxins and waste products from the body, reducing the risk of liver-related conditions. Additionally, calcium D-glucarate aids in the clearance of environmental toxins and excess hormones, supporting overall liver function.

Taking a Holistic Approach to Hormone Health

While calcium D-glucarate offers promising benefits for hormone regulation, it’s essential to adopt a holistic approach to hormone health. Calcium D-glucarate supplementation should be part of a comprehensive strategy that addresses the root causes of hormonal imbalances.

Restoring gut health and promoting a balanced microbiome is crucial in supporting hormone equilibrium. Factors like stress, poor diet, and certain medications can disrupt the delicate balance of gut bacteria, leading to dysbiosis. By eliminating gut disruptors, such as antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs), and adopting a nourishing diet, you can restore your gut microbiome and optimize hormone health.

Dosage & Supplement Safety

There is no standard dose of calcium D-glucarate. It is usually suggested to take 200 to 500 mg, 2-3 times per day.

As with any supplement, it’s important to consider safety when incorporating calcium D-glucarate into your routine. There is limited data on the potential side effects of calcium D-glucarate, and there is no recommended dosage for its use. Pregnant or nursing individuals and children should avoid calcium D-glucarate supplements due to the lack of safety data in these populations.

It’s also important to note that the supplement industry is not regulated in the same way as prescription drugs by the FDA. This means that the quality and safety of supplements can vary. When choosing a calcium D-glucarate supplement, look for third-party testing certifications and consult with a healthcare professional or registered dietitian to ensure the product is safe and appropriate for your individual needs.


If you are considering taking a calcium D-glucarate supplement, it’s important to be aware of potential interactions with medications. Calcium D-glucarate can affect the way the liver breaks down certain drugs, which may decrease their effectiveness. It’s crucial to discuss any potential interactions with your healthcare provider, especially if you are taking medications that are metabolized by the liver.


Calcium D-glucarate, with its potential to support hormone regulation, liver detoxification, and cancer prevention, has emerged as a valuable tool in promoting optimal hormone health. By inhibiting beta-glucuronidase and facilitating estrogen clearance, calcium D-glucarate aids in maintaining hormonal equilibrium.

Disclaimer: The information provided in this article is for informational purposes only and should not be considered as medical advice. Always consult with a qualified healthcare professional before making any dietary or lifestyle changes or starting any supplementation regimen.

Order calcium D-glucarate and receive up to 5-15% off. Apply code RIS385 at check-out if not already applied.

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